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  • Title: Mutagenicity of methylglyoxal in coffee.
    Author: Kasai H, Kumeno K, Yamaizumi Z, Nishimura S, Nagao M, Fujita Y, Sugimura T, Nukaya H, Kosuge T.
    Journal: Gan; 1982 Oct; 73(5):681-3. PubMed ID: 6762317.
    Abstract:
    Major carbonyl compounds from a extract of ground roasted coffee beans were identified as 5-hydroxymethylfurfural, acetol, glyoxal, methylglyoxal and diacetyl. Among these carbonyl compounds, methylglyoxal showed considerable mutagenic activity toward Salmonella typhimurium TA100 without S9 mix (around 100,000 revertants/mg). More than 50% of the total mutagenic activity of coffee can be accounted for by the activity of methylglyoxal.
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