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  • Title: Prostaglandin E1-induced glucagon secretion under propranolol treatment in a case of idiopathic hyperglucagonemia.
    Author: Shimoyama R, Hirayama A, Moriya H.
    Journal: Hokkaido Igaku Zasshi; 1982 Nov; 57(6):722-6. PubMed ID: 6763911.
    Abstract:
    To see how prostaglandin E1 (PGE1) directly effects on the islet cells, PGE1 (200 ng/min) was infused into the celiac artery for 10 min in a patient with idiopathic hyperglucagonemia pretreated with propranolol (80 mg/day, for 5 days). Plasma immunoreactive glucagon (IRG), which had been suppressed to 568 pg/ml by the pretreatment, increased to 1,358 pg/ml at the end of infusion, and it remained over the basal value for 30 min. Plasma immunoreactive insulin (IRI) reached maximum at 5 min and decreased thereafter. These results suggest the possibility of the stimulatory effects of PGE1, not mediated by beta-adrenergic system, on glucagon secretion from alpha cells.
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