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  • Title: A comparative study of zopiclone and flunitrazepam in insomniacs seen by general practitioners.
    Author: Wickstrøm E, Barbo SE, Dreyfus JF, Jerkø D, Kleiven R, Slåttbrekk R, Stray Tønnesen JN.
    Journal: Int Pharmacopsychiatry; 1982; 17 Suppl 2():165-72. PubMed ID: 6765241.
    Abstract:
    A double-blind crossover trial was conducted in 42 outpatients of either sex in order to obtain information on the properties of 7.5 mg of zopiclone in a general practice setting compared with 2 mg of flunitrazepam. Each patient went through two periods of treatment, each period lasting 10 days. A comparison of the effect of the drugs showed a significant difference with regard to effectiveness and sleep latency favoring flunitrazepam. When patient's preferences were analyzed there was a highly significant difference favoring flunitrazepam both for effectiveness and tolerance. The side effects from both drugs were generally mild.
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