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  • Title: [Plasmodium berghei: antibody response and protective immunity induced by vaccination].
    Author: Casaglia O, Zenobi P, Bucci A, Stiffel C, Biozzi G.
    Journal: Parassitologia; 1982 Dec; 24(2-3):121-7. PubMed ID: 6765341.
    Abstract:
    The authors have studied the behaviour of Swiss mice and of 5 inbred strains of mice in order to investigate: the protective effect, in the homologous infection test, of six vaccine inoculations of irradiated parasites belonging to two strains of Plasmodium berghei: ISTISAN and K173; the capacity to produce humoral antibodies after vaccine treatments and during infection; the probable correlation between the high antibody titre and the protection against infection. The results of the present study show that the antibody response plays a precise role in the immunity induced by vaccination. There is a certain degree of correlation, which is more evident for K173 vaccine, between the level of antibody response during infection and the protective efficacy of vaccination.
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