These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Characteristics of neoplastic progression and tumor behavior in skin carcinogenesis by different methods: an experimental study.
    Author: Stenbäck F.
    Journal: Oncology; 1980; 37(3):163-8. PubMed ID: 6767211.
    Abstract:
    Characteristics of chemically induced skin tumor formation by different methods were studied in 600 Swiss mice. A large dose of 9,10-dimethylbenz(a)anthracene (DMBA) alone or followed by 12-0-tetradecanoyl-phorbol-13-acetate(tpa) and a small dose of DMBA followed by TPA or DMBA repeatedly induced papillomas in 80--90% of the animals. Of these 44--65% regressed and 11--16% became malignant. Keratoacanthomas, observed mainly in repeated DMBA treated animals, were seen to arise de novo in 1--12% of the animals, or from papillomas, 3--12%, they became malignant in 4--9% of the animals. Squamous cell carcinomas were formed de novo in 1--8% of the animals or from papillomas or keratoacanthomas in 10--14% of the animals. Duration of experiment and degree of malignancy related to size of tumor and level of invasion. It is concluded that tumor formation is a stepwise process, with the different types of treatment affecting different aspects of tumor formation to a varying degree.
    [Abstract] [Full Text] [Related] [New Search]