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  • Title: Genetic differences between C57BL/6 and DBA/2 mice in the inductions of UDP-glucuronyl transferases for 3-hydroxybenzo(a)pyrene, p-nitrophenol, and bilirubin by 3-methylcholanthrene.
    Author: Nemoto N, Takayama S.
    Journal: Toxicol Lett; 1980 Jan; 5(1):45-50. PubMed ID: 6769180.
    Abstract:
    In C57BL/6 mice, aryl hydrocarbon hydroxylase (AHH) increased 1 day after treatment with 3-methylcholanthrene, and induction of UDP-glucuronyl transferases for 3-hydroxybenzo(a)pyrene, p-nitrophenol and bilirubin in the liver microsomes was observed 2 to 5 days later. In DBA/2 mice, neither AHH nor transferase activities were influenced by 3-methylcholanthrene. These results suggest that induction of activating and detoxicating enzymes is genetically linked.
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