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  • Title: Influence of manganese ions on the contraction of the guinea-pig isolated vas deferens.
    Author: Sugimoto J, Hanasaki K, Takemoto H, Shintani H.
    Journal: Clin Exp Pharmacol Physiol; 1980; 7(2):225-9. PubMed ID: 6769625.
    Abstract:
    1. The CaCl2-induced contraction of guinea-pig isolated vas deferens, pretreated with tetrasodium edetate and then transferred to edetate-free sucrose medium, was increased in the presence of MnCl2 in extremely low concentrations (0.005-0.01 mmol/l) but was suppressed by the salt in concentrations higher than 1.0 mmol/l. 2. The KCl-induced contraction of the preparation, kept in a sucrose medium without edetate-pretreatment, was suppressed by MnCl2 (0.005-0.5 mmol/l) in a concentration-dependent manner. 3. The noradrenaline-induced contraction of the preparation kept in Locke's solution, was not influenced by MnCl2 in concentrations lower tha 0.1 mmol/l but was inhibited by higher concentrations (0.1-1.0 mmol/l).
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