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  • Title: Plasma progesterone levels in normal and pregnant Chinese women and effects of contraceptives on them.
    Author: Gu ZP, Wang WC, Lu RF, Jiang XJ.
    Journal: Chin Med J (Engl); 1980 Aug; 93(8):523-7. PubMed ID: 6772402.
    Abstract:
    Progesterone concentrations in peripheral plasma were determined by competitive protein binding assay during normal human menstrual cycles and in pregnancy. In addition, to investigate the mode of action of anordrin (a postcoital pill) and AF-75 (an effective antifertility nonsteroid in animals) and to evaluate their clinical efficacy, the effects of these 2 chemicals on plasma progesterone levels were also studied. 33 women with normal menstrual cycle and fertility gave blood samples on various days before and after ovulation, according to basal body temperature changes. During the follicular phase, the plasma progesterone level was less than 1 ng/ml (mean .39). After ovulation, the progesterone levels rose gradually, reaching maximal values of 7-15 ng/ml 6-9 days before menstruation. Then the concentrations fell off gradually to below 2 ng/ml on the day before or on the first day of menses. 77 pregnant women at various stages of pregnancy gave blood samples. Plasma progesterone levels during early pregnancy were similar to those of luteal phase. The concentrations gradually rose to a peak in late pregnancy, with the maximal figure being over 130 ng/ml, although there were individual variations. 10 women of child-bearing age were given 7.5 mg of anordrin daily 1-5 days before ovulation, 5 times. Plasma progesterone levels on various days after ovulation were assayed and compared with untreated control cycles. Ovulation did occur in every medicated cycle, but the maximal progesterone values in luteal phase were lower than those of untreated cycles (P .01), and luteal periods were shortened (P .05). Administration of AF-75 showed no conspicuous effect on ovulation or development of corpus luteum in normal women.
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