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  • Title: Variations in the distribution of glycosaminoglycans in the uterine cervix of the pregnant woman.
    Author: Cabrol D, Breton M, Berrou E, Visser A, Sureau C, Picard J.
    Journal: Eur J Obstet Gynecol Reprod Biol; 1980 Jun; 10(5):281-7. PubMed ID: 6772487.
    Abstract:
    A study was made of the modifications of glycosaminoglycans in the uterine cervix and the relationship to gestation. These substances are essential constituents of connective tissue, and a modification of their concentration could affect the physical and chemical characteristics of the cervix. Glycosaminoglycans were extracted from cervical biopsies obtained from pregnant and non-pregnant women. This study showed dermatan sulfte to be quantitatively the most important glycosaminoglycan in the cervix of both the groups studied, and that a significant decrease in the concentration of both dermatan sulfate and chondroitin sulfates occurred in the biopsies obtained just after delivery. This was related to a decrease of collagen in the cervix at the end of gestation, as the proteoglycans containing dermatan sulfate are principally associated with collagen.
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