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  • Title: A radiopharmaceutical and clinical comparison of 99mTc-Sn-hydroxymethylene diphosphonate with 99mTc-Sn-hydroxyethylidene diphosphonate.
    Author: Silberstein EB.
    Journal: Radiology; 1980 Sep; 136(3):747-51. PubMed ID: 6773104.
    Abstract:
    A comparison of 99mTc labeled hydroxyethylidene diphosphonate (99mTc-HEDP) and hydroxymethylene diphosphonate (99mTc-HMDP), two bone scanning agents differing by a single methyl group, was performed in 20 patients. In nine patients, no difference in scan quality was found. Of the other 11, HMDP had significantly better bone delineation (p = 0.012), lower soft tissue background (p = 0.001), and improved overall scan quality (p = 0.012) in 10, while HEDP was preferred for bone delineation and overall quality in only a single patient. No significant difference in lesion detection was noted.
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