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  • Title: Comparative effects of two commercially available blood collection tubes on plasma concentrations of drugs.
    Author: Steyn JM, Müller FO.
    Journal: S Afr Med J; 1980 Jan 26; 57(4):129-31. PubMed ID: 6773155.
    Abstract:
    Two commercially available blood collection systems (Venoject and Vacutainer) were investigated for their effect on the plasma concentrations of a variety of drugs. Vacutainer tubes adversely affected the following drugs: propranolol, penbutolol and quinidine, whereas Venoject tubes had no effect on the plasma concentrations of these drugs. Neither collection system had any effect on the plasma concentrations of the following drugs: acebutolol, the main metabolite of acebutolol (DL-1-(2-acetyl-4-acetamidophenoxy)-2-hydroxy-3-isopropylaminopropane), diazepam, N-demethyldiazepam, digoxin, ethosuximide, salicylic acid, valproic acid, warfarin and carbamazepine.
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