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  • Title: End-tidal partial pressure of CO2 as an estimate of arterial partial pressure of CO2 during various ventilatory regimens in halothane-anesthetized dogs.
    Author: Hightower CE, Kiorpes AL, Butler HC, Fedde MR.
    Journal: Am J Vet Res; 1980 Apr; 41(4):610-2. PubMed ID: 6773449.
    Abstract:
    The correlation between end-tidal partial pressure of CO2 (PETCO2) and arterial PCO2 (PaCO2) was studied in six halothane-anesthetized dogs maintained under four different ventilatory regimens: (A) spontaneous breathing; (B) assisted positive-pressure ventilation; (C) intermittent manual inflation; and (D) ventilator-controlled breathing. For procedures A, B, and D together, there was a strong correlation between PETCO2 and PaCO2 (r = 0.8) that was highly significant at P less than 0.0001 for PETCO2 values between 31.3 and 61 mm of Hg. In spontaneous and controlled breathing, PETCO2 is representative of PaCO2 and provides a useful noninvasive tool for monitoring the patient maintained under general anesthesia. Furthermore, data suggest that any ventilatory support of the anesthetized patient markedly improves blood gas and acid-base status compared with that of the unsupported, spontaneously breathing animal.
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