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  • Title: [Sulfonamide-dependent growth of a strain of Escherichia coli K12 Thy- on Mueller-Hinton medium].
    Author: Frelat G, Dassa E, Boquet PL.
    Journal: C R Seances Acad Sci D; 1980 Jun 09; 290(21):1365-8. PubMed ID: 6773682.
    Abstract:
    The Mueller Hinton medium does not allow the growth of Escherichia coli Thy- strains. This effect is due to the presence of uridine (or a derived compound) which interferes with the function of thymidine phosphorylase. The presence of sulphonamides, in some E. coli K12 Thy- mutants, overcomes this inhibition. The same phenomenon of rescue by sulphonamides has been reproduced in a minimal medium containing thymine and uridine. The biochemical and clinical implications of this observation are discussed.
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