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  • Title: Hemoglobin Hasharon [alpha 247 (CD5)Asp leads to His beta 2] linked to alpha-Thalassemia in northern Italian carriers. Hematological and biosynthetic studies.
    Author: Mavilio F, Marinucci M, Massa A, Fontanarosa PP, Tentori L, Cappellozza G.
    Journal: Acta Haematol; 1980; 63(6):305-11. PubMed ID: 6774563.
    Abstract:
    This report is concerned with the evaluation of hematological parameters and of both relative (%) and absolute (mean pg/cell) quantities of the abnormal Hemoglobin (Hb) Hasharon in 53 heterozygous carriers and 7 double heterozygotes for Hb Hasharon and beta-thalassemia from 43 apparently unrelated families living in the province of Rovigo (northern Italy). Biosynthetic studies are also reported. The data strongly suggest the presence of an alpha-thalassemia-2 determinant closely linked to the alpha Hasharon-chain locus. Selective advantage of heterozygotes carrying such alpha-haplotype would explain the relatively high frequency of Hb Hasharon (0.23%) in northeastern Italy, a past-endemic malaria region. The interaction between Hb Hasharon and beta-thalassemia results in preferential decrease of the abnormal Hb level.
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