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  • Title: Blood-gas tension measurement in anaesthesia by bubble equilibration and mass spectrometry.
    Author: Mapleson WW, Willis BA, Williams B.
    Journal: Br J Anaesth; 1980 Nov; 52(11):1061-70. PubMed ID: 6775647.
    Abstract:
    If a small bubble gas is equilibrated with a volume of blood the partial pressures of the components of the bubble after equilibration approximate to the original tensions in the blood. A method is described in which the bubble is analysed by a respiratory mass spectrometer connected to a mini-computer. The normal respiratory monitoring function of the mass spectrometer need be interrupted for only 20 s for each sample and the complete equilibration and analysis procedure takes only 3 min. Theoretical studies, experimental tests and records of experimental usage show that, in a subject anaesthetized with halothane in nitrous and oxygen, tension can be measured with an overall SD of 5% for carbon dioxide and halothane and, certain reservations, an SD of about 3% for nitrous oxide.
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