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  • Title: Clinical evaluation of long-term treatment with levo-norgestrel and testosterone enanthate in normal men.
    Author: Foegh M, Nicol K, Petersen IB, Schou G.
    Journal: Contraception; 1980 Jun; 21(6):631-40. PubMed ID: 6775869.
    Abstract:
    Thirteen healthy men (25-35 years) with proven fertility were scheduled for long-term treatment (> 12 months) with levo-norgestrel (500 micrograms daily) and testosterone enanthate (200 mg monthly). The volunteers were regularly investigated prior to, during and after treatment. Seven volunteers withdrew from medication after 1 to 12 months of treatment; three due to psychological side effects, one because of stiffness of a finger joint, two for personal reasons and one for unspecified reasons. Sperm counts were significantly decreased during treatment and in 7 volunteers the sperm counts were < 5 x 10(6)/ml. However, two of these volunteers exhibited a breakthrough in sperm counts after 12 and 13 months of a 16-month treatment period. Serum testosterone, serum LH and serum FSH were significantly decreased during treatment, but returned, as did sperm counts, to normal levels after withdrawal of treatment. No rebound effect was seen. Potency and libido remained unchanged. No toxicological side effects were observed and finally no consistent changes were seen in blood coagulation parameters. This study evaluated the effect of longterm treatment (more than 12 months) with levo-norgestrel and testosterone enanthate on spermatogenesis, potency, libido, hematology; liver function, and blood coagulation factors and quantitative aspects of recovery of spermatogenesis. 13 men aged 25-35 years who had proven fertility were given longterm levonorgestrel (500 mcg daily) and testosterone enanthate (200 mg monthly). 7 of 13 withdrew between 1 and 12 months of initation for various reasons including psychological side effects, finger stiffness, and other personal reasons. After at least 12 months of treatment, sperm counts were significantly decreased during treatment, and in 7 volunteers the sperm counts were less than 5 X 10(6) per ml. At 12-13 months of treatment, however, 2 subjects experienced a breakthrough in sperm counts. Levels of testosterone, luteinizing hormone, and follicle stimulating hormone and measured in serum and found to be significant decreased during treatment. The levels returned to normal, along with sperm counts, after cessation of treatment. No rebound effect was seen. Potency and libido were unchanged throughout treatment. No consistent changes in blood coagulation factors were found, and no toxicological side effects were encountered.
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