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  • Title: Pepsin 1 secretion in chronic peptic ulceration.
    Author: Walker V, Taylor WH.
    Journal: Gut; 1980 Sep; 21(9):766-71. PubMed ID: 6776016.
    Abstract:
    In patients with peptic ulceration, both vagal stimulation by insulin hypoglycaemia and stimulation by pentagastrin cause pepsin 1 to be secreted into gastric juice. There is a secretory threshold for pepsin 1, below which only pepsins 3 and 5 are secreted. Pepsin 1 accounts for an increasing proportion of the total peptic activity/ml of gastric juice as the total activity increases. Higher concentrations of pepsin 1 in the basal gastric secretion occurred significantly more frequently in patients with duodenal ulcer than with gastric ulcer. In these patients there may be an increased 'background' secretory drive.
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