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Pubmed for Handhelds

PUBMED FOR HANDHELDS

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  • Title: Intracranial self-stimulation in mice using a modified hole-board task: effects of d-amphetamine.
    Author: Kokkinidis L, Zacharko RM.
    Journal: Psychopharmacology (Berl); 1980; 68(2):169-71. PubMed ID: 6776561.
    Abstract:
    Mice implanted with stimulating electrodes in the lateral hypothalamus demonstrated reliable self-stimulation rates when given the opportunity to break a photobeam in a modified hole-board task. Self-stimulation rates were enhanced by low dosages of d-amphetamine but were depressed by high dosages. The dose-dependent effects of amphetamine could not be accounted for by changes in exploratory hole-board activity and were discussed in terms of an interaction between the rewarding properties of electrical brain stimulation and the reinforcing properties of amphetamine administration.
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