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  • Title: Constitutional delay of growth and adolescence.
    Author: Lee PA, Hogan MJ.
    Journal: Growth; 1980 Jun; 44(2):147-51. PubMed ID: 6777262.
    Abstract:
    In order to evaluate possible abnormalities among males with constitutional delay of growth and adolescence, hormonal responses and interrelationships have been extensively evaluated in a young man with a documented history of this condition and compared with young men with a history of normal puberty as controls. Normal hypothalamic-pituitary sensitivity to circulating sex steroids and a normal end-organ response (nitrogen and phosphorus retention) to testosterone stimulation were found. There was, however, a decreased gonadal (testosterone) response to gonadotropin (HCG) stimulation and a decreased pituitary response to clomiphene stimulation. These decreased responses could explain the observed adolescent delay in growth and maturation observed in these individuals.
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