These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Teratology study in the mouse using a prostaglandin and a prostaglandin synthetase inhibitor.
    Author: Marsk L.
    Journal: Toxicol Lett; 1980 Oct; 6(6):423-6. PubMed ID: 6777908.
    Abstract:
    Prostaglandin F2 alpha alone and in combination with sodium salicylate, was administered i.m. to pregnant CBA mice at various times on day 9 of gestation. A high frequency of rib malformations (90%) was recorded whereas the resorption rate was moderate (18%). When combining prostaglandin treatment (25 mg/kg i.m.) with sodium salicylate (500 mg/kg i.m.), the resorption rate increased. The malformation frequency remained unchanged except for the group with combined treatment at 10 a.m. (=maximum teratogenic period for salicylate induced rib malformations). This treatment resulted in a high frequency of maternal death; the resorption frequency was 75% and the surviving foetuses were malformed.
    [Abstract] [Full Text] [Related] [New Search]