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  • Title: Involvement of calcium in mitogenic and immunoglobulin responses in bovine lymphocytes.
    Author: Atluru D, Sloane ED, Johnson DW, Muscoplat CC.
    Journal: Am J Vet Res; 1980 Aug; 41(8):1319-22. PubMed ID: 6778272.
    Abstract:
    Removal of calcium from cultures of bovine splenic lymphoid cells with ethyleneglycol-bis-(2-amino ethylether)-N,N'-tetraacetic acid (EGTA) caused significant suppression of pokeweed mitogen-induced immunoglobulin (Ig) biosynthesis. It was found that removal of calcium for 48 hours of a 5-day culture significantly altered Ig biosynthesis. Re-addition of calcium after 48 hours did not restore Ig synthesis. The EGTA caused significant (P < 0.05) suppression of DNA synthesis when calcium was removed from concanavalin A- and purified protein derivative-stimulated peripheral blood lymphocyte cultures. Further, removal of calcium for 48 hours of 4-day cultures significantly altered the DNA synthesis in mitogen- and antigen-stimulated cultures.
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