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  • Title: [Effect of the multiple peroral administration of carminomycin on the body of animals].
    Author: Gol'dberg LE, Vertogradova TP, Filippos'iants ST, Belova IP, Shepelevtseva NG.
    Journal: Antibiotiki; 1978 Jul; 23(7):611-7. PubMed ID: 677851.
    Abstract:
    Toxicity of carminomycin used orally for many times was mainly evident from suppression of blood formation, the level of the suppression being dependent on the antibiotic dose. Carminomycin had a low suppressing effect on the white blood in rats. At low doses even moderate leucocytosis was observed. The indices of the functional state of the liver, kidneys, sugar blood levels, content of glycogen and fat in the liver, relative mass of the rat organs after repeated oral administrations of karminomycin to the animals remained mainly unchanged. A change in wave T on the ECG of the dogs treated with high doses of the antibiotic was registered. Histological examination of the organs and tissues of the animals killed after repeated oral administrations of carminomycin revealed pathological changes only in the spleen and thin intestine. Such changes were not more pronounced than those after repeated intravenous administration of the equivalent doses of the antibiotic (by the effect on the blood formation). This allowed the author to recommend the oral administration route for carminomycin trials in clinics.
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