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  • Title: Localisation of 7-12-dimethylbenz(a)anthracene induced chromatid breaks and sister chromatid exchanges in chromosomes 1 and 2 of bone marrow cells of rat in vivo.
    Author: van Kesteren-van Leeuwen AC, Natarajan AT.
    Journal: Chromosoma; 1980; 81(3):473-81. PubMed ID: 6778675.
    Abstract:
    The frequency of chromatid breaks associated with sister chromatid exchanges at the break point was determined in rat bone marrow cells treated in vivo with 7-12 DMBA, during the late S phase of the cell cycle. The chromosomal aberrations and SCEs were scored in the same cells. Under the experimental conditions employed, more than 40% of the chromatid breaks were found to be associated with an SCE, a frequency expected according to Revell's hypothesis for the formation of chromatid breaks.
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