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  • Title: Synthesis and aldose reductase inhibitory activity of 7-sulfamoylxanthone-2-carboxylic acids.
    Author: Pfister JR, Wymann WE, Mahoney JM, Waterbury LD.
    Journal: J Med Chem; 1980 Nov; 23(11):1264-7. PubMed ID: 6779009.
    Abstract:
    A series of xanthone-2-carboxylic acids substituted in the 7 position with sulfamoyl and other groups was synthesized and assayed in vitro for inhibition of aldose reductase isolated from rabbit lenses. At a concentration of 10(-6) M, the N-methyl-N-(2-hydroxyethyl)sulfamoyl derivative 14 produced an 83% inhibition of aldose reductase. The structural requirements for this type of activity are discussed.
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