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  • Title: Biphasic effects of a potent enkephalin analogue (D-Met2,Pro5)-enkephalinamide and morphine on locomotor activity in mice.
    Author: Székely JI, Miglécz E, Rónai AZ.
    Journal: Psychopharmacology (Berl); 1980; 71(3):299-301. PubMed ID: 6779336.
    Abstract:
    The effects of morphine and a potent enkephalin analogue on spontaneous locomotion have been compared in mice. In doses of 3-10 mg/kg SC both compounds induced a brief reduction of motor activity followed by a period of behavioral hyperactivity. Similar receptorial mechanisms are suggested in mediation of their motor effects.
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