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  • Title: Topographical localization of intracellular immunoglobulins in hairy cells by immunoelectron microscopy.
    Author: Martelli MF, Falini B, Tabilio A, Aversa F.
    Journal: Acta Haematol; 1980; 64(5):251-5. PubMed ID: 6779481.
    Abstract:
    Ultrastructural characterization and localization of intracellular immunoglobulin in peripheral blood mononuclear cells from a patient with hairy cell leukemia were studied by the direct immunoperoxidase technique. Approximately 20--30% of hairy cells stained positive for gamma-heavy and K-light chains, and this staining was limited to certain rough endoplasmic reticulum profiles. These ultrastructural findings can be considered an additional argument for the B cell origin of hairy cells.
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