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  • Title: Case report: successful treatment of an idiopathic acquired factor VIII inhibitor with unusual features.
    Author: Makinen D, Mant MJ.
    Journal: Am J Med Sci; 1980; 280(3):179-83. PubMed ID: 6779631.
    Abstract:
    A patient with an idiopathic acquired factor VIII inhibitor is described. Unusual features of this patient's illness were measurable factor VIII (4 to greater than 20%) despite the presence of inhibitor, and continued spontaneous bleeding despite these factor VIII levels. Successful treatment on both a short-term and a long-term basis--with neutralizing doses of human factor VIII concentrate and with chlorambucil, respectively--is reported. It is concluded that in patients with this type of inhibitor factor VIII, assays may not provide a reliable prediction of the potential for bleeding and that chlorambucil therapy warrants further study.
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