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  • Title: Effect of PEEP on lung water content in experimental noncardiogenic pulmonary edema.
    Author: Miller WC, Rice DL, Unger KM, Bradley BL.
    Journal: Crit Care Med; 1981 Jan; 9(1):7-9. PubMed ID: 6780267.
    Abstract:
    After administration of monocrotaline to dogs to produce noncardiogenic pulmonary edema, one-half of the animals (controls) were treated with intermittent positive pressure breathing (IPPV), and one-half with that ventilation plus the addition of 10 cm H2O of positive end-expiratory pressure (PEEP). After 6 h, the animals treated with PEEP demonstrated significantly better arterial oxygenation and reduced AaDO2, but lung water, quantitated either postmortem or in vivo by indicator-dilution techniques, was no less than controls. Although PEEP improves gas exchange, it fails to modify the degree of pulmonary edema represent.
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