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  • Title: Genetic control of contact hypersensitivity. I. I-A subregion as well as non-H-2 loci codes for the gene of 2,4-dinitro-1-fluorobenzene antigen.
    Author: Okuda K, Ishii N, Ikezawa Z, Tani K, Ishigatsubo Y.
    Journal: Eur J Immunol; 1980 Dec; 10(12):969-71. PubMed ID: 6781912.
    Abstract:
    As a first step in determining the genetic control of contact hypersensitivity in mice, 2,4-dinitro-1-fluorobenzene (DNFB) was applied to induce ear swellings. Studies with congenic and recombinant inbred strains of mice revealed that the DNFB contact hypersensitivity is controlled by the I-A subregion, as well as non-H-2 regions. The results presented suggest that the major histocompatibility complex-linked immune response genes seem to be playing an important role in the contact hypersensitivity to the DNFB antigen.
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