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  • Title: Threonine as a carbon source for Escherichia coli.
    Author: Chan TT, Newman EB.
    Journal: J Bacteriol; 1981 Mar; 145(3):1150-3. PubMed ID: 6782087.
    Abstract:
    Threonine can be used aerobically as the sole source of carbon and energy by mutants of Escherichia coli K-12. The pathway used involves the conversion of threonine via threonine dehydrogenase to aminoketobutyric acid, which is further metabolized by aminoketobutyric acid ligase, forming acetyl coenzyme A and glycine. A strain devoid of serine transhydroxymethylase uses this pathway and excretes glycine as a waste product. Aminoketobutyric acid ligase activity was demonstrated after passage of crude extracts through Sephadex G100.
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