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  • Title: Antigonadotropic activity of two fractions of melatonin-free pineal extract separated by ultrafiltration.
    Author: Damian E, Ianăş O, Bădescu I.
    Journal: Endocrinologie; 1980; 18(4):243-6. PubMed ID: 6782646.
    Abstract:
    Using the mouse uterus weight test and the rat ventral prostate weight test in basal conditions and under exogenous stimulation, the activity of 2 fractions of molecular weight above and under 10,000 daltons obtained by ultrafiltration of a melatonin-free pineal extract was tested against a total pineal extract and the same extract subjected to dialysis. The results showed that the larger fraction is predominantly anti-LH whereas the smaller fraction is anti-FSH. The antigonadotropic activity of the total and partially purified pineal extract against the effects of pineal melatonin and arginine-vasotocin is discussed.
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