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  • Title: Treatment of prostatic carcinoma by gonadotropin inhibition with danazol. A preliminary report.
    Author: Freedman DL, Carlström K, Esposti PL, Hedlund PO.
    Journal: Scand J Urol Nephrol Suppl; 1980; 55():173-5. PubMed ID: 6782665.
    Abstract:
    The effect of an oral gonadotropin agent--Danazol--on 5 patients with prostatic carcinoma was investigated. A phase 2 pilot study, using a combination of repeated clinical findings, hormone analyses and cytological examinations, allowed some assessment of results after 16 weeks. There was a marked fall in gonadotropin and testosterone serum levels in all patients. Despite a minor rate of cancer remission, results of clinical and cytological examinations were encouraging enough to stimulate further investigations.
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