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  • Title: [Is myositis in chronic polyarthritis using d-penicillamine drug-induced?].
    Author: Schlumpf U, Bussmann HU, Jerusalem F.
    Journal: Schweiz Med Wochenschr; 1981 Jan 03; 111(1):29-35. PubMed ID: 6782670.
    Abstract:
    Myositis was diagnosed twenty months after starting treatment with d-penicillamine in a patient suffering from uncomplicated rheumatoid arthritis for nearly three years. The diagnosis was established by electromyographic investigation and by biopsy. In this patient d-penicillamine had been intermittently increased to a dose over 1 g per day and then reduced because of mild proteinuria. The appearance of myositis during d-penicillamine therapy, its immediate regression on discontinuing the drug, and the absence of signs of vasculitis or other extraarticular manifestations in this patient suggest that this complication may be drug-induced. The clinical course is compared with isolated cases reported in the literature. The significance of this rare side effect is discussed.
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