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  • Title: Studies on the role of calcium in the control of thromboxane B2 production.
    Author: Best LC, Bone EA, Jones PB, Russell RG.
    Journal: Artery; 1980; 8(5):487-93. PubMed ID: 6783015.
    Abstract:
    5-hydroxytryptamine (5-ht) secretion and thromboxane B2 (TxB2) production by platelet-rich plasma in response to the Ionophore A23187 or the sulphydryl group reagent N-ethyl maleimide (NEM) were potentiated in the presence of EDTA. No such potentiation by EDTA was observed using aspirin-treated platelets. The addition of Ca2+ and also Mg2+ to suspensions of washed human platelets reduced the rate and extent of TxB2 formation in response to thrombin, A23187, collagen or NEM. In contrast, Sr2+ resulted in spontaneous TxB2 production and 5-HT secretion.
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