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  • Title: [Mathematical description and study of the folic acid cycle reactions].
    Author: Vorontsov IN, Greshilov MM, Belousova AK, Gerasimova GK.
    Journal: Biokhimiia; 1980 Jan; 45(1):83-97. PubMed ID: 6783126.
    Abstract:
    A general description of the folic acid cycle and associate reactions of thymidilate, purines, methionine and serine biosyntheses is presented as a system of differential equations. The concrete models of this reaction complex as well as methotrexate transport into the leukemia L 1210 and Ehrlich ascite tumour cells and the dynamic inhibition of the target enzyme--dihydrofolate reductase--by methotrexate have been described and investigated. The adequacy of mathematical models to the experimental data has been demonstrated.
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