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  • Title: Effects of piretanide, bumetanide and frusemide on electrolyte and urate excretion in normal subjects.
    Author: Roberts CJ, Homeida M, Roberts F, Bogie W.
    Journal: Br J Clin Pharmacol; 1978 Aug; 6(2):129-33. PubMed ID: 678389.
    Abstract:
    1. The pharmacological actions of a new short acting loop diuretic were investigated in nine healthy male subjects and compared with those of frusemide and bumetanide. Subjects received 6 mg piretanide/day, 40 mg frusemide/day or 1 mg bumetanide/day for a period of 1 week. 2. Comparison of effects following the first dose administered showed that 6 mg piretanide is of similar potency to 40 mg frusemide in terms of diuresis, natriuresis and kaliuresis but is less potent than 1 mg bumetanide. 3. All three diuretics caused a decrease in urate excretion and a rise in serum uric acid. 4. Piretanide was well tolerated. Further investigation is required to ascertain what clinical advantage it offers over frusemide and bumetanide.
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