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  • Title: [Amyloidosis in a mixed pattern. Sensitivity to colchicine and melphalan].
    Author: Frustaci A, Gentiloni N, Feoli F.
    Journal: Minerva Med; 1981 Apr 14; 72(15):957-60. PubMed ID: 6784038.
    Abstract:
    The Authors describe a case of systemic amyloidosis with hepatic renal, intestinal and presumably cardiac involvement in the course of multiple myeloma (light K chain type). Notwithstanding the presumptions of the pathogenesis of amyloidosis and the capacity of colchicine to inhibit amyloid synthesis in rats treated with casein, the form in question derived little benefit from the association of colchicine (0.5 mg t.i.d.) and Melphalan (cycles of 4 days every 6 weeks - 0.25 mg/Kg/die).
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