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  • Title: Maintenance chrysotherapy in rheumatoid arthritis: a comparison of 2 dose schedules.
    Author: Griffin AJ, Gibson T, Huston G, Taylor A.
    Journal: Ann Rheum Dis; 1981 Jun; 40(3):250-3. PubMed ID: 6787995.
    Abstract:
    Maintenance treatment with chrysotherapy was given to 44 rheumatoid patients after a total of 1.0 g weekly injections of sodium aurothiomalate. 21 patients continued with 50 mg injections every 2 weeks, and 23 patients received the same dose at 4-week intervals. Their progress was followed over 1 year, after which time their clinical improvements were equally well sustained. Toxicity was greater in those patients receiving fortnightly injections. Five patients suffered a relapse after 8 months. These were not related to the frequency of injections nor to the serum gold levels. There appeared to be no advantage in maintenance injections at fortnightly intervals.
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