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Title: The effects of sustained lung inflation on the pattern of breathing in man. Author: Pearson SB, Heath JR. Journal: Clin Sci (Lond); 1981 Jun; 60(6):667-74. PubMed ID: 6788429. Abstract: 1. Continuous positive-pressure breathing (CPPB) at airway pressures of 0.65-1.00 kPa above ambient pressure has been used to produce a sustained inflation of the lungs of approximately 1 litre in six normal male subjects. 2. Lung inflation produced a reduction in the ventilatory response to carbon dioxide inhalation by slow rebreathing in oxygen over approximately 45 min, with a reduction in the slope of the VE/Pet,CO2 and VT/Pet,CO2 relations (Pet,CO2, = end-tidal PCO2). 3. The pattern of breathing is altered, so that for any given expired minute ventilation (VE), tidal volume (VT) is reduced with a fall in breath duration (Tt) resulting from a decrease in inspiratory time (Ti) with no change in expiratory time (Te). 4. The break point on the VT/Ti relation is lowered.[Abstract] [Full Text] [Related] [New Search]