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  • Title: The proportion of Hb A2 is higher in sickle cell trait than in normal homozygotes.
    Author: Whitten WJ, Rucknagel DL.
    Journal: Hemoglobin; 1981; 5(4):371-8. PubMed ID: 6788729.
    Abstract:
    The proportion of Hb A2 was 3.53 +/- 0.94 per cent in the blood of 69 persons with sickle cell trait (A/S) and 2.88 +/- 0.69 per cent in a like number with a normal (A/A) genotype using a radial immunodiffusion assay. This differs significantly at the 0.1% level by the paired comparison technique. It is proposed that this effect is due to the impaired association of beta S with alphaA chains allowing more of the latter to combine with delta-chains. A similar phenomenon may account for the increased proportion of Hb A2 observed in beta-thalassemia. The proportion of Hb F did not differ in the two genotypes.
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