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  • Title: [Inhibitory action of diphosphonate on the development of pancreatic concrements (experiment with EHDP (author's transl)].
    Author: Klemm G, Putzke HP.
    Journal: Dtsch Z Verdau Stoffwechselkr; 1981; 41(3):128-34. PubMed ID: 6790262.
    Abstract:
    The application of the diphosphonate EHDP (ethane-I-hydroxy-I,I-diphosphonate) prior to the commencement of a calciphylactic experiment (SELYE) inhibits the interstitial calcification and fixation of apatite in the pancreas of female rats (dosage: 20 mgEHDP i. p. per 150 g body mass). Thus the inhibitory potency of EHDP on soft tissue calcification is confirmed. Previously, on the basis of experimental results, a therapeutic administration of this substance in the field of clinical pancreatology could not be derived because the most of human intraductal calculi is composed of calcium carbonate.
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