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  • Title: Absence of thyroid-stimulating antibody and long acting thyroid stimulator in relatives of Graves' disease patients.
    Author: Banovac K, Zakarija M, McKenzie JM, Witte A, Sekso M.
    Journal: J Clin Endocrinol Metab; 1981 Sep; 53(3):651-3. PubMed ID: 6790561.
    Abstract:
    None of the 76 euthyroid relatives of patients with Graves' disease had detectable LATS in their serum nor was thyroid-stimulating antibody (TSAb), assessed by an increment of cAMP in human thyroid slices, detected in any of the 60 sera tested. Seven of 41 were slightly positive for TSH binding-inhibiting immunoglobulin (TBII). Nineteen of 73 sera were positive (greater than 1:1600) for antibody to thyroid antimicrosomal antigen, of which 4 were also positive (greater than 1:400) for antibody to thyroglobulin; 3 of the 19 had a slightly elevated basal TSH which rose excessively after TRH. Thus, although these euthyroid relatives had evidence of thyroid immunological defects, a thyroid-stimulating antibody was not found.
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