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  • Title: Analytical methods for quantitative and qualitative analysis of naltrexone and metabolites in biological fluids.
    Author: Wall ME, Brine DR.
    Journal: NIDA Res Monogr; 1981; 28():52-65. PubMed ID: 6791013.
    Abstract:
    Analytical procedures for the determination of naltrexone and metabolites have been presented. The basic procedure involves the use of radiolabeled drugs and thin layer chromatography. Naltrexone, 6 beta-naltrexol and 2-hydroxy-3-O-methyl-6 beta-naltrexol were found by both the TLC procedure and combined gas chromatography-mass spectrometry. The presence of 3-O-methyl-6 beta-naltrexol was indicated by the TLC method, but this metabolite could not be found by mass spectrometry.
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