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  • Title: [Immunochemical analysis and protective properties of components of Pseudomonas aeruginosa mucus with different molecular weights].
    Author: Zaĭdner IG, Palkina NA, Stanislavskiĭ ES, Landsman NM.
    Journal: Zh Mikrobiol Epidemiol Immunobiol; 1981 Apr; (4):92-7. PubMed ID: 6791415.
    Abstract:
    P. aeruginosa slime has been separated into fractions XM-300 (3 X 10(5) daltons and more), XM-100 (1 X 10(5) = 3 X 10(5) daltons), PM-30 (3 X 10(4) = 1 X 10(5) daltons) and PM-10, (1 X 10(4) = 3 X 10(4) daltons) by ultrafiltration. The high-molecular slime components (3 X 10(4) daltons and more) have been found to be serologically more active than the low-molecular components (1 X 10(4) = 3 X 10(4) daltons). As shown in experiments on mice, both high-molecular toxic and low-molecular nontoxic slime components have protective activity, but the high-molecular components are more active than the low-molecular ones. The slime components stimulate the formation of immunity to homologous and partially heterologous P. aeruginosa strains in mice. Antigenic relationship between the slime components (especially the high-molecular ones) and the corresponding lipopolysaccharides has been noted.
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