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  • Title: [Treatment of hypercalcemia of tumoral origin with two diphosphonates].
    Author: Jung A, van Ouwenaller C, Chantraine A, Courvoisier B.
    Journal: Schweiz Med Wochenschr; 1980 Nov 29; 110(48):1822-4. PubMed ID: 6792698.
    Abstract:
    Two diphosphonates, EHDP (disodium etidronate, or ethane-hydroxy-diphosphonate) and Cl2MDP (disodium clodronate, or dichloromethylene-diphosphonate) were injected in various doses in 8 patients who had had one or more episodes of malignant hypercalcemia. All patients responded well to the drugs after a time lapse of 2-10 days. Tolerance of the drugs was excellent. EHDP, and especially Cl2MDP, are promising agents for the treatment of hypercalcemia and the inhibition of bone resorption in malignant disorders.
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