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  • Title: Mutagenicity study of Remsen-Fahlberg saccharin and contaminants.
    Author: Eckhardt K, King MT, Gocke E, Wild D.
    Journal: Toxicol Lett; 1980 Nov; 7(1):51-60. PubMed ID: 6794189.
    Abstract:
    Saccharin and contaminants of commercial Remsen-Fahlberg saccharin were studied for mutagenic potential with the use of the Salmonella/microsome test, Basc-test in Drosophila melanogaster and micronucleus test in mice. In none of these tests were mutagenic effects of saccharin observed. Likewise, the ortho- and para-sulfamoylbenzoic acids (OSBA and PSBA) were ineffective. Para-toluenesulfonamide (PTS) and the major contaminant ortho-toluene-sulfonamide (OTS) exhibited weak mutagenic effects in a modified Salmonella/microsome test and in Drosophila. These results do not indicate mutagenic and therewith correlated carcinogenic potential of saccharin, but they emphasize the possible activity of contaminants.
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