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  • Title: The effects of oral diazepam premedication on blood gases.
    Author: El Mikatti N.
    Journal: Ann R Coll Surg Engl; 1981 Nov; 63(6):429-31. PubMed ID: 6794417.
    Abstract:
    Blood gas analysis was performed before and 1 h after 10 mg oral diazepam premedication on 50 adult male patients undergoing different surgical operations. There was a significant (p less than 0.01) decrease in arterial oxygen tension, a significant (p less than 0.01) increase in alveolar--arterial oxygen tension difference, and no significant change in arterial carbon dioxide tension or pH after administration of the drug. It is concluded that diazepam given by mouth 1 h before operation increases venous admixture. It is suggested therefore that oral diazepam premedication should be given cautiously to patients with impaired cardiorespiratory reserve, preferably without adding a narcotic drug.
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