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  • Title: Treatment of angina pectoris with metoprolol. A comparison between Durules administered once daily and tablets administered twice daily.
    Author: Orö L.
    Journal: Ann Clin Res; 1981; 13 Suppl 30():58-60. PubMed ID: 6794419.
    Abstract:
    Seventeen patients suffering from angina pectoris completed a double-blind trial comparing the efficacy and safety of metoprolol Durules administered once daily and metoprolol tablets administered twice daily both at a daily dosage of 200 mg. In terms of anginal attacks and nitroglycerine consumption, there was no difference between the two regimens. Neither the diurnal distribution of attacks nor the patient interview revealed any significant differences between the two regimens. Heart rate, blood pressure and plasma levels of metoprolol were also similar on conventional tablets 100 mg b.d. and Durules 200 mg once daily. These findings indicate that once daily administration of metoprolol Durules is an effective and safe therapy in angina pectoris.
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