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  • Title: Rat intestinal microvillus membrane sucrase-isomaltase is a single high molecular weight protein and fully active enzyme in the absence of luminal factors.
    Author: Montgomery RK, Sybicki MA, Forcier AG, Grand RJ.
    Journal: Biochim Biophys Acta; 1981 Oct 13; 661(2):346-9. PubMed ID: 6794628.
    Abstract:
    Sucrase-isomaltase immunoprecipitated from brush border of an intestinal transplant lacking pancreatic proteases was found to be a single, high molecular weight protein. Elastase digestion converted this protein into two subunits which co-migrated on electrophoresis with those normally found on the microvillus membrane. The high molecular weight form had full sucrase and isomaltase activities.
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