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  • Title: [Binding of a tetrabenazine derivative to the monoamine transporter of the chromaffin granule membrane].
    Author: Scherman D, Jaudon P, Henry JP.
    Journal: C R Seances Acad Sci III; 1981 Oct 05; 293(4):221-4. PubMed ID: 6794869.
    Abstract:
    [2-3H] dihydrotetrabenazine (2-hydroxy-3-isobutyl-9-10-dimethoxy-1,2,3,4,6,7 hexahydro-11 bH-benzo [a] quinolizine), a derivative of tetrabenazine obtained by tritiated borohydride reduction, binds to the membrane of purified chromaffin granules. The binding equilibrium has been studied by filtration and by centrifugation of ligand-membrane complexes. Saturable binding sites (190 pmol/mg protein), characterized by a dissociation equilibrium constant KD = 90 nM have been described. The correlation existing between dihydrotetrabenazine site occupancy and noradrenaline uptake inhibition indicates that these sites are located on the monoamine transporter.
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